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Humira is used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis and plaque psoriasis. Doctors have also prescribed Humira to treat Crohn’s disease. The drug works by reducing the effects of tumor necrosis factor in the body, which causes inflammation. It is classified as a Tumor Necrosis Factor inhibitor (TNF). Humira is manufactured by Abbott Laboratories and it has been estimated to have made $6.5 billion in one year. The FDA approved the drug in 2002.
Since 2002, the label for Humira has been changed more than 20 times to warn about newly-discovered side effects. The label now warns of opportunistic infections, malignancies, nervous system disorders, heart failure and tuberculosis. Many of these side effects affect children and young adults.
Humira has also been connected to lymphoma, leukemia and skin cancer. In 2009, the FDA ordered manufacturers to add a black box warning about the increased risk of developing cancer while taking Humira. Patients taking the drug have also been seen to develop a rare type of cancer called hepatosplenic T-cell lymphoma (HSTCL), which is often fatal.
In 2011, Abbott warned physicians and patients about the risk of Hepatitis B, liver failure and death in connection to the use of Humira.
Humira has been linked to serious infections and autoimmune disorders including transverse myelitis and multiple sclerosis. Both diseases affect the brain and the spinal cord, along with causing nerve and visual impairment.
Serious side effects may include:
Less serious Humira side effects may include:
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