Indomethacin is a nonsteroidal antiinflammatory drug, or NSAID. This type of drug is often used to manage pain, stiffness, tenderness and swelling related to rheumatoid arthritis or osteoarthritis. The medication works by stopping the body from producing a substance that contributes to inflammation.

Side Effects/Warnings

Indomethacin can increase the risk of heart attacks and strokes. Patients who have a history of heart disease or whose families suffer from heart disease are more likely to have a heart attack or stroke than other patients. Patients who have recently had coronary bypass surgery should not take this medication.

This medication also increases the risk of an ulcer or stomach perforation. Talk to your doctor as soon as possible if you have stomach problems accompanied by blood in the stool.

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